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The effect of acetaminophen ingestion on cortico-spinal excitability

Mauger, Alexis R., Hopker, James G. (2013) The effect of acetaminophen ingestion on cortico-spinal excitability. Canadian Journal of Physiology and Pharmacology, 91 (2). pp. 187-189. ISSN 0008-4212. (doi:10.1139/cjpp-2012-0213) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:36241)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1139/cjpp-2012-0213

Abstract

Acetaminophen (ACT) facilitates the inhibition of voltage-gated calcium and sodium currents, which may effect cortico-spinal excitability. Twelve subjects ingested acetaminophen or a placebo and underwent transcranial magnetic stimulation to assess the motor evoked potential (MEP), and cortical silent period (CSP). ACT significantly increased MEP response (P > 0.05) but had no effect on CSP (P > 0.05). This indicates that ACT increases MEP and should be controlled for in studies where these measures are of interest.

Item Type: Article
DOI/Identification number: 10.1139/cjpp-2012-0213
Uncontrolled keywords: paracetamol, motor cortex, transcranial magnetic stimulation, cortical silent period, fatigue
Subjects: Q Science > QM Human anatomy
Q Science > QP Physiology (Living systems)
R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC1200 Sports medicine
Divisions: Faculties > Sciences > School of Sport and Exercise Sciences
Depositing User: Lex Mauger
Date Deposited: 12 Nov 2013 16:10 UTC
Last Modified: 28 Jan 2020 04:05 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/36241 (The current URI for this page, for reference purposes)
Mauger, Alexis R.: https://orcid.org/0000-0001-6685-5800
Hopker, James G.: https://orcid.org/0000-0002-4786-7037
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