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Structural Guided Scaffold Phage Display Libraries as a Source of Bio-Therapeutics

Howard, Mark J., Rowe, Michelle L. (2013) Structural Guided Scaffold Phage Display Libraries as a Source of Bio-Therapeutics. Structural Guided Scaffold Phage Display Libraries as a Source of Bio-Therapeutics, 8 (n/a). e70452-e70452. ISSN 1932-6203. (KAR id:35490)

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Abstract

We have developed a structurally-guided scaffold phage display strategy for identification of ligand mimetic biotherapeutics.

target for imaging and therapy of many types of solid cancer. NMR structure analysis showed that RGD-helix structures are

(scFv) libraries with synthetic VH-CDR3 encoding RGD-helix hairpins with helices of differing pitch, length and amino acid

and D34p, demonstrated: specific binding to recombinant and cellular avb6; inhibition of avb6-dependent cell and ligand

xenografts. NMR analysis established that both the D25p and D34p retained RGD-helix structures confirming the success of

developing powerful bio-therapeutics.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculties > Sciences > School of Biosciences > Protein Science Group
Depositing User: M.J. Howard
Date Deposited: 16 Oct 2013 15:59 UTC
Last Modified: 29 May 2019 11:07 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/35490 (The current URI for this page, for reference purposes)
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