Howard, Mark J., Rowe, Michelle L. (2013) Structural Guided Scaffold Phage Display Libraries as a Source of Bio-Therapeutics. Structural Guided Scaffold Phage Display Libraries as a Source of Bio-Therapeutics, 8 (n/a). e70452-e70452. ISSN 1932-6203. (KAR id:35490)
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Abstract
We have developed a structurally-guided scaffold phage display strategy for identification of ligand mimetic biotherapeutics.
target for imaging and therapy of many types of solid cancer. NMR structure analysis showed that RGD-helix structures are
(scFv) libraries with synthetic VH-CDR3 encoding RGD-helix hairpins with helices of differing pitch, length and amino acid
and D34p, demonstrated: specific binding to recombinant and cellular avb6; inhibition of avb6-dependent cell and ligand
xenografts. NMR analysis established that both the D25p and D34p retained RGD-helix structures confirming the success of
developing powerful bio-therapeutics.
Item Type: | Article |
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Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | Divisions > Division of Natural Sciences > School of Biosciences |
Depositing User: | M.J. Howard |
Date Deposited: | 16 Oct 2013 15:59 UTC |
Last Modified: | 16 Feb 2021 12:47 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/35490 (The current URI for this page, for reference purposes) |
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