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Targeting connexin43 expression accelerates the rate of wound repair.

Qiu, Cindy, Coutinho, Petula, Frank, Stefanie, Franke, Susanne, Law, Lee-yong, Martin, Paul, Green, Colin R, Becker, David L (2003) Targeting connexin43 expression accelerates the rate of wound repair. Current Biology, 13 (19). pp. 1697-703. ISSN 0960-9822. (doi:10.1016/j.cub.2003.09.007) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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http://dx.doi.org/10.1016/j.cub.2003.09.007

Abstract

The repair of tissue damage is a key survival process in all organisms and involves the coordinated activation of several cell types. Cell-cell communication is clearly fundamental to this process, and a great deal is known about extracellular communication within the wound site via cytokines. Here we show that direct cell-cell communication through connexin 43 (Cx43) gap junction channels also plays a major role in the wound healing process. In two different wound healing models, incisional and excisional skin lesions, we show that a single topical application of Cx43 antisense gel brings about a transient downregulation of Cx43 protein levels, and this results in a dramatic increase in the rate of wound closure. Cx43 knockdown reduces inflammation, seen both macroscopically, as a reduction in swelling, redness, and wound gape, and microscopically, as a significant decrease in neutrophil numbers in the tissue around the wound. One long-term consequence of the improved rate of healing is a significant reduction in the extent of granulation tissue deposition and the subsequent formation of a smaller, less distorted, scar. This approach is likely to have widespread therapeutic applications in other injured tissues and opens up new avenues of research into improving the wound healing process.

Item Type: Article
DOI/Identification number: 10.1016/j.cub.2003.09.007
Subjects: Q Science
R Medicine
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: S. Frank
Date Deposited: 04 Oct 2013 15:51 UTC
Last Modified: 29 May 2019 11:05 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/35406 (The current URI for this page, for reference purposes)
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