Dynamic changes in connexin expression correlate with key events in the wound healing process.

Coutinho, Petula and Qiu, Cindy and Frank, Stefanie and Tamber, Kamaldeep and Becker, David L (2003) Dynamic changes in connexin expression correlate with key events in the wound healing process. Cell Biology International, 27 (7). pp. 525-541. ISSN 1065-6995. (doi:https://doi.org/10.1016/S1065-6995(03)00077-5) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

Wound healing is a complex process requiring communication for the precise co-ordination of different cell types. The role of extracellular communication through growth factors in the wound healing process has been extensively documented, but the role of direct intercellular communication via gap junctions has scarcely been investigated. We have examined the dynamics of gap junction protein (Connexins 26, 30, 31.1 and 43) expression in the murine epidermis and dermis during wound healing, and we show that connexin expression is extremely plastic between 6 hours and 12 days post-wounding. The immediate response (6 h) to wounding is to downregulate all connexins in the epidermis, but thereafter the expression profile of each connexin changes dramatically. Here, we correlate the changing patterns of connexin expression with key events in the wound healing process.

Item Type: Article
Subjects: Q Science
R Medicine
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: S. Frank
Date Deposited: 04 Oct 2013 15:52 UTC
Last Modified: 06 Jan 2016 10:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/35405 (The current URI for this page, for reference purposes)
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