Schmidt, Ulrike, Ulrike, Beth, Lose, Anna, Kenyon, Martha, DeJong, Hannah, Broadbent, Hannah, Loomes, Rachel, Watson, Charlotte, Ghelani, Shreena, Serpell, Lucy, and others. (2013) The MOSAIC study - comparison of the Maudsley Model of Treatment for Adults with Anorexia Nervosa (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with anorexia nervosa or eating disorder not otherwise specified,anorexia nervosa type: study protocol for a randomized controlled trial. Trials, 14 (160). ISSN 1745-6215. (doi:10.1186/1745-6215-14-160) (KAR id:35171)
PDF
Publisher pdf
Language: English
This work is licensed under a Creative Commons Attribution 4.0 International License.
|
|
Download this file (PDF/383kB) |
|
Request a format suitable for use with assistive technology e.g. a screenreader | |
Official URL: http://dx.doi.org/10.1186/1745-6215-14-160 |
Abstract
Background: Anorexia nervosa (AN) is a biologically based serious mental disorder with high levels of mortality
and disability, physical and psychological morbidity and impaired quality of life. AN is one of the leading causes of
disease burden in terms of years of life lost through death or disability in young women. Psychotherapeutic
interventions are the treatment of choice for AN, but the results of psychotherapy depend critically on the stage of
the illness. The treatment response in adults with a chronic form of the illness is poor and drop-out from treatment
is high. Despite the seriousness of the disorder the evidence-base for psychological treatment of adults with AN is
extremely limited and there is no leading treatment. There is therefore an urgent need to develop more effective
treatments for adults with AN. The aim of the Maudsley Outpatient Study of Treatments for Anorexia Nervosa and
Related Conditions (MOSAIC) is to evaluate the efficacy and cost effectiveness of two outpatient treatments for
adults with AN, Specialist Supportive Clinical Management (SSCM) and the Maudsley Model of Treatment for Adults
with Anorexia Nervosa (MANTRA).
Methods/Design: 138 patients meeting the inclusion criteria are randomly assigned to one of the two treatment
groups (MANTRA or SSCM). All participants receive 20 once-weekly individual therapy sessions (with 10 extra weekly
sessions for those who are severely ill) and four follow-up sessions with monthly spacing thereafter. There is also
optional access to a dietician and extra sessions involving a family member or a close other. Body weight, eating
disorder- related symptoms, neurocognitive and psychosocial measures, and service use data are measured during
the course of treatment and across a one year follow up period. The primary outcome measure is body mass index
(BMI) taken at twelve months after randomization.
Discussion: This multi-center study provides a large sample size, broad inclusion criteria and a follow-up period.
However, the study has to contend with difficulties directly related to running a large multi-center randomized
controlled trial and the psychopathology of AN. These issues are discussed.
Trial Registration: Current Controlled Trials ISRCTN67720902 - A Maudsley outpatient study of treatments for
anorexia nervosa and related conditions.
Item Type: | Article |
---|---|
DOI/Identification number: | 10.1186/1745-6215-14-160 |
Uncontrolled keywords: | Anorexia nervosa, Eating disorder not otherwise specified, Outpatient treatment, Randomized controlled trial, Cost effectiveness |
Subjects: |
H Social Sciences R Medicine > RC Internal medicine |
Divisions: | Divisions > Division for the Study of Law, Society and Social Justice > School of Social Policy, Sociology and Social Research > Personal Social Services Research Unit |
Depositing User: | R. Bass |
Date Deposited: | 11 Sep 2013 10:17 UTC |
Last Modified: | 10 Dec 2022 04:20 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/35171 (The current URI for this page, for reference purposes) |
- Link to SensusAccess
- Export to:
- RefWorks
- EPrints3 XML
- BibTeX
- CSV
- Depositors only (login required):