Molesti, Eleonora, Ferrara, Francesca, Lapini, Giulia, Montomoli, Emanuele, Temperton, Nigel J. (2013) The study of heterosubtypic neutralising antibody responses against H5N1 influenza viruses in human subjects using a comparative serology approach. In: Options for the Control of Influenza VIII, 5-10 Sep 2013, Cape Town. (doi:P2-460) (KAR id:35139)
PDF
Presentation
Language: English |
|
Download (446kB)
Preview
|
Preview |
This file may not be suitable for users of assistive technology.
Request an accessible format
|
|
Official URL http://optionsviii.controlinfluenza.com/ |
Abstract
Background: The continuous rapid genetic and antigenic evolution of H5 subtype influenza viruses
human vaccines and the ability to undertake effective serosurveillance in susceptible populations.
and 2007 and previously found to be positive for antibodies against H5N1 as determined by serial
combination with haemagglutination-inhibition (HI) assays using a clade 1 and a clade 2 H5N1
A/Vietnam/1194/04 H5 and A/chicken/Italy/13474/99 H7 pseudotypes. IC50 neutralizing antibody
10240. Seven of 68 (10.3%) sera were found to be negative against A/Vietnam/1194/04 pseudotypes.
from < 40 (cut-off) to 1:160-320. Forty-seven of 68 (69.1%) sera were found to be negative against
pseudotype assay can efficiently measure cross-reactive antibody responses that are not detected by
three serologic assays (PPN, SRH, HI) measure antibodies with different (functional) overlapping
specificities, contributing to a comprehensive analysis of humoral immunity to influenza viruses.
Item Type: | Conference or workshop item (Poster) |
---|---|
DOI/Identification number: | P2-460 |
Subjects: | Q Science > QR Microbiology > QR355 Virology |
Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
Depositing User: | Nigel Temperton |
Date Deposited: | 06 Sep 2013 14:40 UTC |
Last Modified: | 16 Feb 2021 12:47 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/35139 (The current URI for this page, for reference purposes) |
Temperton, Nigel J.: | ![]() |
- Export to:
- RefWorks
- EPrints3 XML
- BibTeX
- CSV
- Depositors only (login required):