Skip to main content

The study of heterosubtypic neutralising antibody responses against H5N1 influenza viruses in human subjects using a comparative serology approach

Molesti, Eleonora, Ferrara, Francesca, Lapini, Giulia, Montomoli, Emanuele, Temperton, Nigel J. (2013) The study of heterosubtypic neutralising antibody responses against H5N1 influenza viruses in human subjects using a comparative serology approach. In: Options for the Control of Influenza VIII, 5-10 Sep 2013, Cape Town. (doi:P2-460) (KAR id:35139)

PDF Presentation
Language: English
Download (446kB) Preview
[thumbnail of P2-460.pdf]
Preview
This file may not be suitable for users of assistive technology.
Request an accessible format
Official URL
http://optionsviii.controlinfluenza.com/

Abstract

Background: The continuous rapid genetic and antigenic evolution of H5 subtype influenza viruses

human vaccines and the ability to undertake effective serosurveillance in susceptible populations.

and 2007 and previously found to be positive for antibodies against H5N1 as determined by serial

combination with haemagglutination-inhibition (HI) assays using a clade 1 and a clade 2 H5N1

A/Vietnam/1194/04 H5 and A/chicken/Italy/13474/99 H7 pseudotypes. IC50 neutralizing antibody

10240. Seven of 68 (10.3%) sera were found to be negative against A/Vietnam/1194/04 pseudotypes.

from < 40 (cut-off) to 1:160-320. Forty-seven of 68 (69.1%) sera were found to be negative against

pseudotype assay can efficiently measure cross-reactive antibody responses that are not detected by

three serologic assays (PPN, SRH, HI) measure antibodies with different (functional) overlapping

specificities, contributing to a comprehensive analysis of humoral immunity to influenza viruses.

Item Type: Conference or workshop item (Poster)
DOI/Identification number: P2-460
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Nigel Temperton
Date Deposited: 06 Sep 2013 14:40 UTC
Last Modified: 16 Feb 2021 12:47 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/35139 (The current URI for this page, for reference purposes)
Temperton, Nigel J.: https://orcid.org/0000-0002-7978-3815
  • Depositors only (login required):

Downloads

Downloads per month over past year