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Widespread recombination in published animal mtDNA sequences.

Tsaousis, Anastasios D., Martin, D.P., Ladoukakis, E.D., Posada, D., Zouros, E. (2005) Widespread recombination in published animal mtDNA sequences. Molecular Biology and Evolution, 22 (4). pp. 925-33. ISSN 0737-4038. (doi:10.1093/molbev/msi084) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:34995)

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Mitochondrial DNA (mtDNA) recombination has been observed in several animal species, but there are doubts as to whether it is common or only occurs under special circumstances. Animal mtDNA sequences retrieved from public databases were unambiguously aligned and rigorously tested for evidence of recombination. At least 30 recombination events were detected among 186 alignments examined. Recombinant sequences were found in invertebrates and vertebrates, including primates. It appears that mtDNA recombination may occur regularly in the animal cell but rarely produces new haplotypes because of homoplasmy. Common animal mtDNA recombination would necessitate a reexamination of phylogenetic and biohistorical inference based on the assumption of clonal mtDNA transmission. Recombination may also have an important role in producing and purging mtDNA mutations and thus in mtDNA-based diseases and senescence.

Item Type: Article
DOI/Identification number: 10.1093/molbev/msi084
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Anastasios Tsaousis
Date Deposited: 20 Aug 2013 17:15 UTC
Last Modified: 16 Nov 2021 10:12 UTC
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