Building centromeres: home sweet home or a nomadic existence?

Buscaino, Alessia and Allshire, Robin C and Pidoux, Alison (2010) Building centromeres: home sweet home or a nomadic existence? Current Opinion in Genetics and Development, 20 (2). pp. 118-126. ISSN 1879-0380. (doi:https://doi.org/10.1016/j.gde.2010.01.006) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1016/j.gde.2010.01.006

Abstract

Centromere assembly and propagation is governed by genetic and epigenetic mechanisms. A centromere-specific histone H3 variant, CENP-A is strongly favored as the epigenetic mark that specifies centromere identity. Despite the critical importance of centromere function, centromeric sequences are not conserved. This has prompted exploration of other genomic and chromatin features to gain an understanding of where CENP-A is deposited. In this review we highlight recent papers that advance our understanding of how the cell builds a centromere. We focus on what influences the choice of site for CENP-A deposition and therefore the site of centromere formation. We then briefly discuss how centromeres are propagated once the site of centromere assembly is chosen.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Alessia Buscaino
Date Deposited: 12 Jul 2013 08:48 UTC
Last Modified: 23 Apr 2014 10:46 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34593 (The current URI for this page, for reference purposes)
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