Replaying the tape of evolution: Evolving parameters for a simple bacterial metabolism

Chu, Dominique (2013) Replaying the tape of evolution: Evolving parameters for a simple bacterial metabolism. In: IEEE CEC 2013 : IEEE Congress on Evolutionary Computation, 20th - 23rd June, 2013, Cancun, Mexico. (Full text available)

Abstract

Parameter values of biological systems have received comparatively little attention in the past. Particularly computational modellers tend to see them as necessary, but often illusive pieces of information that somehow needs to be inferred. This article is a first attempt to understand whether quantitative information about biological systems, i.e. kinetic parameters, reaction rates, or other constants contain valuable information about the adaptive pressures for which they have evolved. To do this, genetic algorithms are used to evolve parameters for a fixed network structure. The results indicate that the parameters are rather specific to the particular circumstances for which they have evolved. If this is also true for real biological systems, then this suggests that parameter values may be a valuable source of biological information.

Item Type:	Conference or workshop item (Paper)
Subjects:	Q Science > Q Science (General) > Q335 Artificial intelligence
Divisions:	Faculties > Sciences > School of Computing Faculties > Sciences > School of Computing > Applied and Interdisciplinary Informatics Group Faculties > Sciences > School of Computing > Applied and Interdisciplinary Informatics Group > Natural Computation Group Faculties > Sciences > School of Computing > Computational Intelligence Group Faculties > Sciences > School of Computing > Data Science
Depositing User:	Dominique Chu
Date Deposited:	25 Jun 2013 14:10 UTC
Last Modified:	04 Dec 2013 12:56 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/34409 (The current URI for this page, for reference purposes)