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MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.

Robas, Nicola, Mead, Emma J, Fidock, Mark (2003) MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. Journal of Biological Chemistry, 278 (45). pp. 44400-4. ISSN 0021-9258. (doi:10.1074/jbc.M302456200) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34354)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
http://dx.doi.org/10.1074/jbc.M302456200

Abstract

MrgX2 is a recently identified orphan G-protein-coupled receptor whose ligand and physiological function were unknown. Here we describe cortistatin, a neuropeptide for which no specific receptor has been identified previously, as a high potency ligand at MrgX2. Cortistatin has several biological functions including roles in sleep regulation, locomotor activity, and cortical function. Using a "reverse pharmacology" approach, we have identified a number of additional cyclic peptide agonists for MrgX2, determined their rank order of potency, and demonstrated that this receptor has a pharmacological profile distinct from the other characterized members of the Mrg (Mas-related genes) family. In MrgX2-expressing cells, cortistatin-stimulated increases in intracellular Ca2+ but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is Gq-coupled. Immunohistochemical and quantitative PCR studies show MrgX2 to have a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.

Item Type: Article
DOI/Identification number: 10.1074/jbc.M302456200
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Emma Hargreaves
Date Deposited: 21 Jun 2013 14:30 UTC
Last Modified: 16 Nov 2021 10:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34354 (The current URI for this page, for reference purposes)
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