4.13 Thin Filament Regulation

Geeves, Michael A. (2012) 4.13 Thin Filament Regulation. Comprehensive Biophysics, 4 (1). pp. 251-267. ISSN 978-0-12-374920-8. (doi:https://doi.org/10.1016/B978-0-12-374920-8.00416-1) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/B978-0-12-374920-8.00416...

Abstract

The review summarizes the current state of knowledge of the calcium regulation of striated muscle contraction via the thin filament proteins, tropomyosin and troponin. The description focuses on in vitro studies of the thin filament and covers structural, biochemical and dynamic aspects of the thin filament's response to calcium binding. A reductionist approach has allowed many of the transitions to be defined at the level of a single structural unit. Here an emphasis is placed on the co-operative nature of the structural and biochemical transitions of the thin filament and the allosteric relationship between calcium and myosin binding to the thin filament.

Item Type: Article
Uncontrolled keywords: Actin; Allosteric; Calcium; Co-operativity; Coupled equilibria; E-F hand; Inhibitory peptide; Motility; Myosin; Persistence length; Signal peptide; Thin filament; Tropomyosin; Troponin
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Faculties > Sciences > School of Biosciences > Protein Science Group
Depositing User: Michael Geeves
Date Deposited: 06 Jun 2013 15:53 UTC
Last Modified: 20 May 2014 15:39 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34208 (The current URI for this page, for reference purposes)
  • Depositors only (login required):