Skip to main content

The flagellum in malarial parasites.

Sinden, R. E., Talman, A. M., Marques, S R, Wass, Mark N., Sternberg, Michael J.E. (2010) The flagellum in malarial parasites. Current Opinion in Microbiology, 13 (4). pp. 491-500. ISSN 1369-5274. (doi:10.1016/j.mib.2010.05.016) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/j.mib.2010.05.016

Abstract

The malarial parasites assemble flagella exclusively during the formation of the male gamete in the midgut of the female mosquito vector. The observation of gamete formation ex vivo reported by Laveran (Laveran MA: De la nature parasitaire des accidents de l'impaludisme. Comptes Rendues De La Societe de Biologie. Paris 1881, 93:627-630) was seminal to the discovery of the parasite itself. Following ingestion of malaria-infected blood by the mosquito, microgamete formation from the terminally arrested gametocytes is exceptionally rapid, completing three mitotic divisions in just a few minutes, and is precisely regulated. This review attempts to draw together the diverse original observations with subsequent electron microscopic studies, and recent work on the signalling pathways regulating sexual development, together with transcriptomic and proteomic studies that are paving the way to new understandings of the molecular mechanisms involved and the potential they offer for effective interventions to block the transmission of the parasites in natural communities.

Item Type: Article
DOI/Identification number: 10.1016/j.mib.2010.05.016
Subjects: Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Divisions: Faculties > Sciences > School of Biosciences > Protein Science Group
Depositing User: Mark Wass
Date Deposited: 06 Jun 2013 13:14 UTC
Last Modified: 29 May 2019 10:16 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34186 (The current URI for this page, for reference purposes)
Wass, Mark N.: https://orcid.org/0000-0001-5428-6479
  • Depositors only (login required):