Genetic loci influencing kidney function and chronic kidney disease.

Chambers, John C and Zhang, Weihua and Lord, Graham M and van der Harst, Pim and Lawlor, Debbie A and Sehmi, Joban S. and Gale, Daniel P and Wass, Mark N. and Ahmadi, Kourosh R and Bakker, Stephan J L and Beckmann, Jacqui and Bilo, Henk J G and Bochud, Murielle and Brown, Morris J and Caulfield, Mark J and Connell, John M C and Cook, H Terence and Cotlarciuc, Ioana and Davey Smith, George and de Silva, Ranil and Deng, Guohong and Devuyst, Olivier and Dikkeschei, Lambert D and Dimkovic, Nada and Dockrell, Mark and Dominiczak, Anna and Ebrahim, Shah and Eggermann, Thomas and Farrall, Martin and Ferrucci, Luigi and Floege, Jurgen and Forouhi, Nita G and Gansevoort, Ron T and Han, Xijin and Hedblad, Bo and Homan van der Heide, Jaap J and Hepkema, Bouke G and Hernandez-Fuentes, Maria and Hypponen, Elina and Johnson, Toby and de Jong, Paul E and Kleefstra, Nanne and Lagou, Vasiliki and Lapsley, Marta and Li, Yun and Loos, Ruth J F and Luan, Jian'an and Luttropp, Karin and Maréchal, Céline and Melander, Olle and Munroe, Patricia B and Nordfors, Louise and Parsa, Afshin and Peltonen, Leena and Penninx, Brenda W and Perucha, Esperanza and Pouta, Anneli and Prokopenko, Inga and Roderick, Paul J and Ruokonen, Aimo and Samani, Nilesh J and Sanna, Serena and Schalling, Martin and Schlessinger, David and Schlieper, Georg and Seelen, Marc A J and Shuldiner, Alan R and Sjögren, Marketa and Smit, Johannes H and Snieder, Harold and Soranzo, Nicole and Spector, Timothy D and Stenvinkel, Peter and Sternberg, Michael J.E. and Swaminathan, Ramasamyiyer and Tanaka, Toshiko and Ubink-Veltmaat, Lielith J and Uda, Manuela and Vollenweider, Peter and Wallace, Chris and Waterworth, Dawn M and Zerres, Klaus and Waeber, Gerard and Wareham, Nicholas J and Maxwell, Patrick H and McCarthy, Mark I and Jarvelin, Marjo-Riitta and Mooser, Vincent and Abecasis, Goncalo R and Lightstone, Liz and Scott, James and Navis, Gerjan and Elliott, Paul and Kooner, Jaspal S (2010) Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42 (5). pp. 373-5. ISSN 1061-4036. (doi:https://doi.org/10.1038/ng.566) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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http://dx.doi.org/doi:10.1038/ng.566

Abstract

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RZ Other systems of medicine
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Mark Wass
Date Deposited: 06 Jun 2013 13:18 UTC
Last Modified: 06 Jun 2017 11:13 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34185 (The current URI for this page, for reference purposes)
Wass, Mark N.: https://orcid.org/0000-0001-5428-6479
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