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Genetic loci influencing kidney function and chronic kidney disease.

Chambers, John C, Zhang, Weihua, Lord, Graham M, van der Harst, Pim, Lawlor, Debbie A, Sehmi, Joban S., Gale, Daniel P, Wass, Mark N., Ahmadi, Kourosh R, Bakker, Stephan J L, and others. (2010) Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42 (5). pp. 373-5. ISSN 1061-4036. (doi:10.1038/ng.566) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/doi:10.1038/ng.566

Abstract

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

Item Type: Article
DOI/Identification number: 10.1038/ng.566
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RZ Other systems of medicine
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Mark Wass
Date Deposited: 06 Jun 2013 13:18 UTC
Last Modified: 29 May 2019 10:16 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34185 (The current URI for this page, for reference purposes)
Wass, Mark N.: https://orcid.org/0000-0001-5428-6479
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