Chambers, John C, Zhang, Weihua, Lord, Graham M, van der Harst, Pim, Lawlor, Debbie A, Sehmi, Joban S., Gale, Daniel P, Wass, Mark N., Ahmadi, Kourosh R, Bakker, Stephan J L, and others. (2010) Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42 (5). pp. 373-5. ISSN 1061-4036. (doi:10.1038/ng.566) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34185)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://dx.doi.org/doi:10.1038/ng.566 |
Abstract
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1038/ng.566 |
| Subjects: |
Q Science > QH Natural history > QH301 Biology R Medicine > RZ Other systems of medicine |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Mark Wass |
| Date Deposited: | 06 Jun 2013 13:18 UTC |
| Last Modified: | 16 Nov 2021 10:11 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/34185 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Wass, Mark N..
| Creator's ORCID: |
 https://orcid.org/0000-0001-5428-6479
|
|---|---|
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