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The genome of a songbird

Warren, Wesley C., Clayton, David F., Ellegren, Hans, Arnold, Arthur P., Hillier, LaDeana W., Künstner, Axel, Searle, Steve, White, Simon, Vilella, Albert J., Fairley, Susan, and others. (2010) The genome of a songbird. Nature, 464 (7289). pp. 757-762. ISSN 0028-0836. (doi:10.1038/nature08819) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34154)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
http://dx.doi.org/10.1038/nature08819

Abstract

The zebra finch is an important model organism in several fields with unique relevance to human neuroscience. Like other songbirds, the zebra finch communicates through learned vocalizations, an ability otherwise documented only in humans and a few other animals and lacking in the chicken-the only bird with a sequenced genome until now. Here we present a structural, functional and comparative analysis of the genome sequence of the zebra finch (Taeniopygia guttata), which is a songbird belonging to the large avian order Passeriformes. We find that the overall structures of the genomes are similar in zebra finch and chicken, but they differ in many intrachromosomal rearrangements, lineage-specific gene family expansions, the number of long-terminal-repeat-based retrotransposons, and mechanisms of sex chromosome dosage compensation. We show that song behaviour engages gene regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs, transcription factors and their targets. We also show evidence for rapid molecular evolution in the songbird lineage of genes that are regulated during song experience. These results indicate an active involvement of the genome in neural processes underlying vocal communication and identify potential genetic substrates for the evolution and regulation of this behaviour.

Item Type: Article
DOI/Identification number: 10.1038/nature08819
Uncontrolled keywords: Animal behaviour; Genome; Neuroscience; Zebra finch
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Darren Griffin
Date Deposited: 06 Jun 2013 09:11 UTC
Last Modified: 16 Nov 2021 10:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34154 (The current URI for this page, for reference purposes)
Skinner, Benjamin M.: https://orcid.org/0000-0002-7152-1167
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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