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Primordial Germ Cell-Mediated Chimera Technology Produces Viable Pure-Line Houbara Bustard Offspring: Potential for Repopulating an Endangered Species

Milstone, David S., Wernery, Ulrich, Liu, Chunhai, Baskar, Vijay, Guerineche, Zhor, Khazanehdari, Kamal A., Saleem, Shazia, Kinne, Jörg, Wernery, Renate, Griffin, Darren K., and others. (2010) Primordial Germ Cell-Mediated Chimera Technology Produces Viable Pure-Line Houbara Bustard Offspring: Potential for Repopulating an Endangered Species. PLoS ONE, 5 (12). e15824. ISSN 1932-6203. (doi:10.1371/journal.pone.0015824) (KAR id:34151)

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http://dx.doi.org/10.1371/journal.pone.0015824

Abstract

BACKGROUND:

The Houbara bustard (Chlamydotis undulata) is a wild seasonal breeding bird populating arid sandy semi-desert habitats in North Africa and the Middle East. Its population has declined drastically during the last two decades and it is classified as vulnerable. Captive breeding programmes have, hitherto, been unsuccessful in reviving population numbers and thus radical technological solutions are essential for the long term survival of this species. The purpose of this study was to investigate the use of primordial germ cell-mediated chimera technology to produce viable Houbara bustard offspring.

CONCLUSION:

This study demonstrates for the first time that Houbara gPGCs can migrate, differentiate and eventually give rise to functional sperm in the chimeric chicken testis. This approach may provide a promising tool for propagation and conservation of endangered avian species that cannot breed in captivity.

Item Type: Article
DOI/Identification number: 10.1371/journal.pone.0015824
Subjects: R Medicine
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Darren Griffin
Date Deposited: 06 Jun 2013 09:03 UTC
Last Modified: 23 Jan 2020 04:06 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34151 (The current URI for this page, for reference purposes)
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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