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Valproate and valproate-analogues: potent tools to fight against cancer.

Blaheta, Roman A., Nau, Heinz, Michaelis, Martin, Cinatl, Jindrich (2002) Valproate and valproate-analogues: potent tools to fight against cancer. Current Medicinal Chemistry, 9 (15). pp. 1417-33. ISSN 0929-8673. (doi:10.2174/0929867023369763) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.2174/0929867023369763

Abstract

The branched-chain fatty acid valproic acid (VPA) is the most commonly used antiepileptic drug for treating generalized epilepsy. Although originally considered to be of low toxicity, VPA has proved to possess considerable teratogenic potential when applied to the pregnant epileptic women. During the last few years, it has become evident that some of the mechanisms which account for the malformations produced by VPA are related to distinct anti-tumor properties of this compound. This intriguing discovery opens novel aspects for the treatment of tumor patients. In the present review, the biological, biochemical and pharmacological properties of VPA are discussed. Analyses of structure-activity relationships can provide the necessary insight into the molecular structures responsible for the anti-tumor effects.

Item Type: Article
DOI/Identification number: 10.2174/0929867023369763
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Martin Michaelis
Date Deposited: 05 Jun 2013 20:10 UTC
Last Modified: 29 May 2019 10:15 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34124 (The current URI for this page, for reference purposes)
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