Skip to main content

Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells.

Michaelis, Martin, Cinatl, Jaroslav, Anand, Puja, Rothweiler, Florian, Kotchetkov, Rouslan, von Deimling, Andreas, Doerr, Hans Wilhelm, Shogen, Kuslima, Cinatl, Jindrich (2007) Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells. Cancer Letters, 250 (1). pp. 107-16. ISSN 0304-3835. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)

Abstract

The efficacy of Onconase on the growth of a panel of chemosensitive and chemoresistant neuroblastoma cell lines was investigated. Onconase decreased cell viability of chemosensitive (IMR-32, UKF-NB-3) and chemoresistant neuroblastoma cell lines characterised by high expression of P-glycoprotein (P-gp) (UKF-NB-3(r)DOX(20)) or by high P-gp expression in combination with mutated p53 (UKF-NB-3(r)VCR(10), Be(2)-C), in a similar manner. Moreover, Onconase caused cell cycle block in G1 phase and induced caspase-independent cell death. Transmission electron microscope investigations suggested that Onconase-induced autophagy contributes to Onconase-induced cell death. Antitumour activity of Onconase against naïve and drug-resistant neuroblastoma xenografts was confirmed in animals.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Martin Michaelis
Date Deposited: 05 Jun 2013 20:58 UTC
Last Modified: 29 May 2019 10:14 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34097 (The current URI for this page, for reference purposes)
  • Depositors only (login required):