The threat of avian influenza A (H5N1). Part IV: Development of vaccines.

Cinatl, Jindrich and Michaelis, Martin and Doerr, Hans Wilhelm (2007) The threat of avian influenza A (H5N1). Part IV: Development of vaccines. Medical Microbiology and Immunology, 196 (4). pp. 213-25. ISSN 1432-1831. (doi:https://doi.org/10.1007/s00430-007-0052-3) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1007/s00430-007-0052-3

Abstract

Among emerging and re-emerging infectious diseases, influenza constitutes one of the major threats to mankind. In this review series epidemiologic, virologic and pathologic concerns raised by infections of humans with avian influenza virus A/H5N1 are discussed. This fourth part focuses on vaccine development. Several phase I clinical studies with vaccines against H5 viruses have demonstrated limited efficacy compared to seasonal influenza vaccines. To induce protective immunity two immunisations with increased amounts of H5N1 vaccine were required. Novel vaccination strategies that are egg- and adjuvant-independent, broadly cross-reactive and long-lasting are highly desirable.

Item Type: Article
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Martin Michaelis
Date Deposited: 05 Jun 2013 21:12 UTC
Last Modified: 01 Jul 2014 15:37 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34087 (The current URI for this page, for reference purposes)
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