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MAGD Trial-Memantine for Agitation in Alzheimer’s Dementia

Fox, Christopher, Boustani, Malaz, Crugel, Monica, Coulton, Simon, Maidment, Ian D., Ballard, Clive G., Katona, Cornelius (2011) MAGD Trial-Memantine for Agitation in Alzheimer’s Dementia. Journal of the American Geriatrics Society, 59 (S1). ISSN 0002-8614. (doi:10.1111/j.1532-5415.2011.03416.x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1111/j.1532-5415.2011.03416.x

Abstract

Dementia is increasing with current global level of 35 million people (AD International 2010). Behavioural disturbance is common with prevalence levels of 20-80% according to setting and stage of disease (Ballard et al 2009). Agitation and aggression are two of the most problematic. Non medication approaches are first line and have efficacy but medication may still have to be used. Medication has very limited evidence of efficacy e.g.cholinesterase inhibitors (Howard et al 2008) or potential harm e.g. antipsychotics (Ballard et al 2009). The Memantine cochrane reported agitation/aggression, irritability/lability and psychosis possibly reduced. OBJECTIVE: Does memantine improve agitation in dementia DESIGN: Double blind randomized placebo controlled trial SETTING: Nursing Homes PARTICIPANTS: 153 patients with Alzheimer’s dementia INTERVENTION: Memantine vs placebo MEASUREMENTS: Cohen Mansfield Agitation Inventory (CMAI), Neuro-Psychiatric Inventory (NPI), Severe Impairment Battery (SIB), Quality of Life-AD (QOL-AD)

Item Type: Article
DOI/Identification number: 10.1111/j.1532-5415.2011.03416.x
Subjects: R Medicine > R Medicine (General)
Divisions: Faculties > Social Sciences > School of Social Policy Sociology and Social Research > Centre for Health Services Studies
Depositing User: Simon Coulton
Date Deposited: 08 Mar 2013 11:54 UTC
Last Modified: 10 Jun 2019 15:36 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/33364 (The current URI for this page, for reference purposes)
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