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Inflammatory Gene Haplotype-Interaction Networks Involved in Coronary Collateral Formation

Zhang, Jian, Regieli, Jakub J, Schipper, Maria, Entius, Mark M., Liang, Faming, Koerselman, Jeroen, Ruven, Hendrik J.T., van der Graaf, Yolanda, Grobbee, Diederick E, Doevendans, Pieter A. and others. (2008) Inflammatory Gene Haplotype-Interaction Networks Involved in Coronary Collateral Formation. Human Heredity, 66 (4). pp. 252-264. ISSN 0001-5652. (doi:10.1159/000143407) (KAR id:31587)

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Abstract

Objectives: Formation of collateral circulation is an endogenous

mechanism by re-routing blood. Inflammatory responserelated

We explored the genetic basis of collateral formation in man

Nucleotide Polymorphisms (SNPs) in these inflammatory

well as the interactions among them was examined in a cohort

54 candidate SNPs. Patients were classified to the extent of

and a haplotype entropy procedure were applied to search

Multiple testing was addressed by using the false discovery

patients with and 142 without visible collaterals. Among the

of collaterals with the FDR of 0.19. Nine SNPs were

Two sets of coupling haplotypes that predispose to collateral

suggest that collateral formation may arise from the

related genes, which may represent targets in future studies

for risk stratification and therapeutic stimulation of arteriogenesis.

Item Type: Article
DOI/Identification number: 10.1159/000143407
Subjects: Q Science > QA Mathematics (inc Computing science) > QA276 Mathematical statistics
Divisions: Faculties > Sciences > School of Mathematics Statistics and Actuarial Science > Statistics
Depositing User: Jian Zhang
Date Deposited: 11 Oct 2012 17:32 UTC
Last Modified: 13 Feb 2020 04:04 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/31587 (The current URI for this page, for reference purposes)
Zhang, Jian: https://orcid.org/0000-0001-8405-2323
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