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Attenuation of Vibrio fischeri Quorum Sensing Using Rationally Designed Polymers

Piletska, Elena V., Stavroulakis, Georgios, Karim, Kal, Whitcombe, Michael J., Chianella, Iva, Sharma, Anant, Eboigbodin, Kevin E., Robinson, Gary K., Piletsky, Sergey A. (2010) Attenuation of Vibrio fischeri Quorum Sensing Using Rationally Designed Polymers. Biomacromolecules, 11 (4). pp. 975-980. ISSN 1525-7797. (doi:10.1021/bm901451j) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:31408)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1021/bm901451j

Abstract

A first attempt to attenuate the quorum sensing (QS) of a marine heterotroph microorganism, Vibrio fischeri, using signal molecule-sequestering polymers (SSPs) is presented. A set of rationally designed polymers with affinity toward a signal molecule of V. fischeri, N-(?-ketocaproyl)-l-homoserine lactone (3-oxo-C6-AHL) was produced. It is reported that computationally designed polymers could sequester a signal molecule of V. fischeri and prevent QS-controlled phenotypes (in this case, bioluminescence) from being up-regulated. It was proven that the attenuation of bioluminescence of V. fischeri was due to sequestration of the signal molecule by specific polymers and not due to the toxicity of polymer or nonspecific depletion of nutrients. The ability to disrupt the bacterial communication using easy to synthesize and chemically inert polymers could provide a new concept for the development of pharmaceuticals and susceptible device coatings such as catheters.

Item Type: Article
DOI/Identification number: 10.1021/bm901451j
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Susan Davies
Date Deposited: 09 Oct 2012 08:35 UTC
Last Modified: 16 Nov 2021 10:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/31408 (The current URI for this page, for reference purposes)

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