Influenza Virus M2 Ion Channel Protein Is Necessary for Filamentous Virion Formation

Rossman, Jeremy S. and Jing, Xianghong and Leser, George P. and Balannik, Victoria and Pinto, Lawrence H. and Lamb, Robert A. (2010) Influenza Virus M2 Ion Channel Protein Is Necessary for Filamentous Virion Formation. Journal of Virology, 84 (10). pp. 5078-5088. ISSN 0022-538X. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Influenza A virus buds from cells as spherical (∼100-nm diameter) and filamentous (∼100 nm × 2 to 20 μm) virions. Previous work has determined that the matrix protein (M1) confers the ability of the virus to form filaments; however, additional work has suggested that the influenza virus M2 integral membrane protein also plays a role in viral filament formation. In examining the role of the M2 protein in filament formation, we observed that the cytoplasmic tail of M2 contains several sites that are essential for filament formation. Additionally, whereas M2 is a nonraft protein, expression of other viral proteins in the context of influenza virus infection leads to the colocalization of M2 with sites of virus budding and lipid raft domains. We found that an amphipathic helix located within the M2 cytoplasmic tail is able to bind cholesterol, and we speculate that M2 cholesterol binding is essential for both filament formation and the stability of existing viral filaments.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Jeremy Rossman
Date Deposited: 08 Oct 2012 15:55
Last Modified: 05 Jun 2014 13:21
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