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Cisplatin-Resistant Neuroblastoma Cells Express Enhanced Levels of Epidermal Growth Factor Receptor (EGFR) and Are Sensitive to Treatment with EGFR-Specific Toxins

Michaelis, Martin, Bliss, Jennifer, Arnold, Sonja C., Hinsch, Nora, Rothweiler, Florian, Deubzer, Hedwig, Witt, Olaf, Langer, Klaus, Doerr, Hans Wilhelm, Wels, Winfried S., and others. (2008) Cisplatin-Resistant Neuroblastoma Cells Express Enhanced Levels of Epidermal Growth Factor Receptor (EGFR) and Are Sensitive to Treatment with EGFR-Specific Toxins. Clinical Cancer Research, 14 (20). pp. 6531-6537. ISSN 1078-0432. (doi:10.1158/1078-0432.CCR-08-0821) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1158/1078-0432.CCR-08-0821

Abstract

Neuroblastomas frequently show expression of the epidermal growth factor receptor (EGFR) and may therefore be susceptible to EGFR-targeted therapies. Here, EGFR expression and functionality was investigated in parental chemosensitive neuroblastoma cell lines (UKF-NB-3, IMR-32, NLF, SH-SY5Y) and their cisplatin-resistant sublines (UKF-NB-3rCDDP1000, IMR-32rCDDP1000, NLFrCDDP1000, and SH-SY5YrCDDP500). Moreover, the EGFR antibody cetuximab, the EGFR tyrosine kinase inhibitor Tyrphostin B46, and recombinant EGFR-targeted toxins were investigated for their influence on the viability and growth of neuroblastoma cells.

Item Type: Article
DOI/Identification number: 10.1158/1078-0432.CCR-08-0821
Uncontrolled keywords: neuroblastoma; epithelial growth factor; epithelial growth factor receptor; toxin; chemoresistance
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 08 Oct 2012 13:52 UTC
Last Modified: 22 Jan 2020 04:04 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/31386 (The current URI for this page, for reference purposes)
Michaelis, Martin: https://orcid.org/0000-0002-5710-5888
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