Trifluoroacetyl-HYNIC peptides: Synthesis and Tc-99m radiolabeling

Surfraz, M. Bashir-Uddin, King, Robert C., Mather, Stephen J., Biagini, Stefano C. G., Blower, Philip J. (2007) Trifluoroacetyl-HYNIC peptides: Synthesis and Tc-99m radiolabeling. Journal of Medicinal Chemistry, 50 (6). pp. 1418-1422. ISSN 0022-2623. (doi:10.1021/jm061274l) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:3105)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1021/jm061274l

Abstract

Fmoc-lys(HYNIC-Boc)-OH, a precursor for solid-phase synthesis of Tc-99m-labeled peptides, was synthesized efficiently without HPLC purification. HPLC-ESMS showed that deprotection and decoupling of peptide from the resin with trifluoroacetic acid gave initially HYNIC-peptide, which was trifluoroacetylated upon prolonged incubation. The trifluoroacetyl-HYNIC group was hydrolyzed during Tc-99m labeling, rendering deprotection unnecessary. Trifluoroacetyl-HYNIC peptide was Tc-99m-labeled as efficiently, producing the same product, as HYNIC-peptide. These modifications enhance the versatility of HYNIC for Tc-99m peptide labeling.

Item Type:	Article
DOI/Identification number:	10.1021/jm061274l
Subjects:	Q Science > QD Chemistry
Divisions:	Divisions > Division of Natural Sciences > Biosciences Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User:	Jane Griffiths
Date Deposited:	14 May 2008 07:04 UTC
Last Modified:	16 Nov 2021 09:41 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/3105 (The current URI for this page, for reference purposes)

University of Kent Author Information

Surfraz, M. Bashir-Uddin.

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CReDIT Contributor Roles:

Biagini, Stefano C. G..

Creator's ORCID:	https://orcid.org/0000-0002-4713-5127
CReDIT Contributor Roles:

Blower, Philip J..

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