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Design Principles of Transcriptional Logic Circuits

Zabet, Nicolae Radu, Hone, Andrew N.W., Chu, Dominique (2010) Design Principles of Transcriptional Logic Circuits. In: Artificial Life XII Proceedings of the Twelfth International Conference on the Synthesis and Simulation of Living Systems. . pp. 182-196. MIT Press (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:30641)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
http://www.cs.kent.ac.uk/pubs/2010/3036

Abstract

Using a set of genetic logic gates (AND, OR and XOR), we constructed a binary full-adder. The optimality analysis of the full-adder showed that, based on the position of the regulation threshold, the system displays different optimal configurations for speed and accuracy under fixed metabolic cost. In addition, the analysis identified an optimal trade-off curve bounded by these two optimal configurations. Any configuration outside this optimal trade-off curve is sub-optimal in both speed and accuracy. This type of analysis represents a useful tool for synthetic biologists to engineer faster, more accurate and cheaper genes.

Item Type: Conference or workshop item (UNSPECIFIED)
Additional information: Freely available for download at: http://mitpress.mit.edu/catalog/item/default.asp?ttype=2&tid=12433
Uncontrolled keywords: determinacy analysis, Craig interpolants
Subjects: Q Science > QA Mathematics (inc Computing science) > QA 76 Software, computer programming,
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Depositing User: Andrew Hone
Date Deposited: 21 Sep 2012 09:49 UTC
Last Modified: 16 Nov 2021 10:08 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/30641 (The current URI for this page, for reference purposes)
Hone, Andrew N.W.: https://orcid.org/0000-0001-9780-7369
Chu, Dominique: https://orcid.org/0000-0002-3706-2905
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