Design Principles of Transcriptional Logic Circuits

Zabet, Nicolae Radu and Hone, Andrew N.W. and Chu, Dominique (2010) Design Principles of Transcriptional Logic Circuits. In: Artificial Life XII Proceedings of the Twelfth International Conference on the Synthesis and Simulation of Living Systems. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Using a set of genetic logic gates (AND, OR and XOR), we constructed a binary full-adder. The optimality analysis of the full-adder showed that, based on the position of the regulation threshold, the system displays different optimal configurations for speed and accuracy under fixed metabolic cost. In addition, the analysis identified an optimal trade-off curve bounded by these two optimal configurations. Any configuration outside this optimal trade-off curve is sub-optimal in both speed and accuracy. This type of analysis represents a useful tool for synthetic biologists to engineer faster, more accurate and cheaper genes.

Item Type: Conference or workshop item (UNSPECIFIED)
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Uncontrolled keywords: determinacy analysis, Craig interpolants
Subjects: Q Science > QA Mathematics (inc Computing science) > QA 76 Software, computer programming,
Divisions: Faculties > Science Technology and Medical Studies > School of Computing > Computational Intelligence Group
Depositing User: Andrew N W Hone
Date Deposited: 21 Sep 2012 09:49
Last Modified: 23 Jun 2014 08:43
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