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Arrhythmia Caused by a Drosophila Tropomyosin Mutation is Revealed using a Novel Optical Coherence Tomography Instrument

Ma, Lisha, Bradu, Adrian, Podoleanu, Adrian G.H., Bloor, James W. (2010) Arrhythmia Caused by a Drosophila Tropomyosin Mutation is Revealed using a Novel Optical Coherence Tomography Instrument. PLoS ONE, 5 (12). e14348. ISSN 1932-6203. (doi:10.1371/journal.pone.0014348) (KAR id:30209)

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http://dx.doi.org/10.1371/journal.pone.0014348

Abstract

Background: Dilated cardiomyopathy (DCM) is a severe cardiac condition that causes high mortality. Many genes have been confirmed to be involved in this disease. An ideal system with which to uncover disease mechanisms would be one that can measure the changes in a wide range of cardiac activities associated with mutations in specific, diversely functional cardiac genes. Such a system needs a genetically manipulable model organism that allows in vivo measurement of cardiac phenotypes and a detecting instrument capable of recording multiple phenotype parameters.

Conclusion: These results demonstrate the capability of our OCT instrument to characterize in detail cardiac activity in genetic models for heart disease in Drosophila.

Item Type: Article
DOI/Identification number: 10.1371/journal.pone.0014348
Additional information: This is available as OPEN ACCESS by clicking on the URL.
Subjects: R Medicine > R Medicine (General)
Divisions: Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: J. Harries
Date Deposited: 20 Aug 2012 15:01 UTC
Last Modified: 26 Jan 2020 04:04 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/30209 (The current URI for this page, for reference purposes)
Bradu, Adrian: https://orcid.org/0000-0002-6890-1599
Podoleanu, Adrian G.H.: https://orcid.org/0000-0002-4899-9656
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