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Red Blood Cell Thermal Fluctuations: Comparison Between Experiment and Molecular Dynamics Simulations

Hale, John P., Marcelli, Gianluca, Parker, Kim H., Winlove, C. Peter, Petrov, Peter G. (2009) Red Blood Cell Thermal Fluctuations: Comparison Between Experiment and Molecular Dynamics Simulations. Soft Matter, 5 (19). pp. 3603-3606. ISSN 1744-683X. (doi:10.1039/b910422d) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:30205)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1039/b910422d

Abstract

We outline a new method of analysis of thermal shape fluctuations of red blood cells, based on comparison between experiments and coarse-grained molecular dynamics simulations. The fluctuations of 2D equatorial contours of red blood cells are recorded experimentally using fast phase-contrast video microscopy, from which the fluctuation spectrum is calculated. The spectrum is compared to the corresponding contour fluctuation spectrum obtained from a finite-temperature particle-dynamics simulation, modelling a cell with bending and shear elasticity and conserved volume and surface area. We demonstrate that the simulation correctly describes the mean cell shape as well as the membrane thermal fluctuations, returning physically sound values for the relevant membrane elastic moduli.

Item Type: Article
DOI/Identification number: 10.1039/b910422d
Subjects: Q Science > QH Natural history > QH324.2 Computational biology
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Engineering and Digital Arts
Depositing User: J. Harries
Date Deposited: 20 Aug 2012 09:13 UTC
Last Modified: 16 Feb 2021 12:41 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/30205 (The current URI for this page, for reference purposes)
Marcelli, Gianluca: https://orcid.org/0000-0002-7475-7327
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