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MAGD Trial-Memantine for Agitation in Alzheimer’s Dementia

Fox, Christopher, Boustani, Malaz, Crugel, Monica, Maidment, Ian D., Ballard, Clive G., Katona, Cornelius, Livingston, Gill, Adrian, T., Coulton, Simon, Macshane, R. and others. (2011) MAGD Trial-Memantine for Agitation in Alzheimer’s Dementia. In: Journal of the American Geriatrics Society. 59 (s1). S65-S66. (doi:10.1111/j.1532-5415.2011.03416.x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29706)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
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OBJECTIVE: Does memantine improve agitation in dementia

DESIGN: Double blind randomized placebo controlled trial

SETTING: Nursing Homes

PARTICIPANTS: 153 patients with Alzheimer’s dementia

INTERVENTION: Memantine vs placebo

MEASUREMENTS: Cohen Mansfield Agitation Inventory

(CMAI), Neuro-Psychiatric Inventory (NPI), Severe Impairment

Battery (SIB), Quality of Life-AD (QOL-AD)

RESULTS:CMAI-there was no statistically significant difference

for mean change- memantine vs placebo p=0.17.

NPI-9 point difference between memantine vs placebo p=0.01

Hallucinations, aberrant motor behaviour and sleep-p=0.03

Agitation, disinhibition and irritability-p=0.001

SIB-Memantine compared to placebo had a strong augmentation

of the percent change from baseline to week 12 p=0.02

QOL-AD-Memantine group are significantly more satisfied

about the contact with friends compared to the patients treated with

placebo p=0.04.


In this study of agitated AD patients benefit was not shown for

agitation on the CMAI with memantine but the NPI reached signficance

and the agitation, disinhibiton and irritability cluster improvement

was significant. Cognition and quality of life improved. We believe

that this study supports the use of Memantine in agitated

patients with Alzheimer’s dementia

Item Type: Conference or workshop item (Paper)
DOI/Identification number: 10.1111/j.1532-5415.2011.03416.x
Additional information: AGS Annual meeting, Thursday 12 May 2011
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Divisions > Division for the Study of Law, Society and Social Justice > School of Social Policy, Sociology and Social Research > Centre for Health Services Studies
Depositing User: Simon Coulton
Date Deposited: 26 Jun 2012 14:27 UTC
Last Modified: 16 Nov 2021 10:07 UTC
Resource URI: (The current URI for this page, for reference purposes)
Coulton, Simon:
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