MAGD Trial-Memantine for Agitation in Alzheimer’s Dementia

Fox, Christopher and Boustani, Malaz and Crugel, Monica and Maidment, Ian D. and Ballard, Clive G. and Katona, Cornelius and Livingston, Gill and Adrian, T. and Coulton, Simon and Macshane, R. (2011) MAGD Trial-Memantine for Agitation in Alzheimer’s Dementia. In: The American Geriatrics Society Annual Scientific Meeting, May 11–14, 2011, The Gaylord National Hotel, National Harbor, MD. (doi: (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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OBJECTIVE: Does memantine improve agitation in dementia DESIGN: Double blind randomized placebo controlled trial SETTING: Nursing Homes PARTICIPANTS: 153 patients with Alzheimer’s dementia INTERVENTION: Memantine vs placebo MEASUREMENTS: Cohen Mansfield Agitation Inventory (CMAI), Neuro-Psychiatric Inventory (NPI), Severe Impairment Battery (SIB), Quality of Life-AD (QOL-AD) RESULTS:CMAI-there was no statistically significant difference for mean change- memantine vs placebo p=0.17. NPI-9 point difference between memantine vs placebo p=0.01 Hallucinations, aberrant motor behaviour and sleep-p=0.03 Agitation, disinhibition and irritability-p=0.001 SIB-Memantine compared to placebo had a strong augmentation of the percent change from baseline to week 12 p=0.02 QOL-AD-Memantine group are significantly more satisfied about the contact with friends compared to the patients treated with placebo p=0.04. CONCLUSION: In this study of agitated AD patients benefit was not shown for agitation on the CMAI with memantine but the NPI reached signficance and the agitation, disinhibiton and irritability cluster improvement was significant. Cognition and quality of life improved. We believe that this study supports the use of Memantine in agitated patients with Alzheimer’s dementia

Item Type: Conference or workshop item (Paper)
Additional information: AGS Annual meeting, Thursday 12 May 2011
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Social Sciences > School of Social Policy Sociology and Social Research > Centre for Health Services Studies
Depositing User: Tony Rees
Date Deposited: 26 Jun 2012 14:27 UTC
Last Modified: 28 May 2014 15:52 UTC
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