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Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model - Effect of solute structure

Jouyban, Abolghasem, Fakhree, Mohammad A. A., Ghafourian, Taravat, Saei, A.A., Acree, William Eugene (2008) Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model - Effect of solute structure. Die Pharmazie - An International Journal of Pharmaceutical Sciences, 63 (2). pp. 113-121. ISSN 0031-7144. (doi:10.1691/ph.2008.7670) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1691/ph.2008.7670

Abstract

Deviations of the predicted solubilities using the Jouyban-Acree model from experimental data were correlated to the structural descritptors of the drugs computed by HyperChem® software. The proposed models are able to predict the solubility in water-cosolvent mixtures and reduced the mean percentage deviations (MPD) of predicted solubilities from 24%, 48%, and 53% to 16%, 33% and 38%, respectively for water-propylene glycol, water-ethanol and water-polyethylene glycol 400 mixtures, with the overall improvement in prediction capability of the model being �13%.

Item Type: Article
DOI/Identification number: 10.1691/ph.2008.7670
Additional information: Unmapped bibliographic data: PY - 2008/// [EPrints field already has value set] AD - Faculty of Pharmacy, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [Field not mapped to EPrints] AD - Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [Field not mapped to EPrints] AD - Medway School of Pharmacy, University of Kent and Greenwich, Chatham, United Kingdom [Field not mapped to EPrints] AD - Pharmaceutical Nanotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [Field not mapped to EPrints] AD - Department of Chemistry, University of North Texas, Denton, TX, United States [Field not mapped to EPrints] AD - Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran [Field not mapped to EPrints] JA - Pharmazie [Field not mapped to EPrints]
Uncontrolled keywords: acetazolamide, acetylsalicylic acid, adenine, adenosine, alcohol, aminophenazone, ampicillin, atropine, benzamide, benzoic acid, bumetanide, butyl paraben, butylcaine, carbamazepine, chloramphenicol, cimetidine, clofazimine, cortisone, dapsone, diflunisal, equilin, estriol, estrone, fenbufen, glafenine, macrogol, propylene glycol, solvent, unindexed drug, water, article, computer program, drug solubility, Jouyban Acree model, mathematical model, prediction, solute, Algorithms, Chemistry, Pharmaceutical, Computer Simulation, Data Interpretation, Statistical, Ethanol, Models, Chemical, Models, Statistical, Pharmaceutical Preparations, Polyethylene Glycols, Software, Solubility, Solvents, Water
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 29 Dec 2013 18:36 UTC
Last Modified: 29 May 2019 08:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/29426 (The current URI for this page, for reference purposes)
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