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Solubility prediction of paracetamol in water-ethanol-propylene glycol mixtures at 25 and 30°C using practical approaches

Jouyban, Abolghasem, Azarmir, Olduz, Mirzaei, Shahla, Hassanzadeh, Davoud, Ghafourian, Taravat, Acree, William Eugene, Nokhodchi, Ali (2008) Solubility prediction of paracetamol in water-ethanol-propylene glycol mixtures at 25 and 30°C using practical approaches. Chemical and Pharmaceutical Bulletin, 56 (4). pp. 602-606. ISSN 00092363 (ISSN). (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Abstract

The solubility of paracetamol in water-ethanol-propylene glycol binary and ternary mixtures at 25 and 30°C was determined using flask shake method. The generated data extended the solubility database for further computational investigations and also was used to assess the prediction capability of the Jouyban-Acree model. A new version of the model was proposed for modeling the solubility data in water-cosolvent mixtures with the cosolvent concentration of <50% which is required in pharmaceutical formulations. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental solubilities. The overall MPD of the Jouyban-Acree model and the log-linear model of Yalkowsky for the entire composition range of the cosolvents were 11.0±8.7 and 55.4±17.8%, respectively; the corresponding values for the predicted solubilities in mixtures having a cosolvent concentration of <50% were 12.0±9.1 and 22.0±11.0%. © 2008 Pharmaceutical Society of Japan.

Item Type: Article
Additional information: Unmapped bibliographic data: PY - 2008/// [EPrints field already has value set] AD - Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran [Field not mapped to EPrints] AD - Pharmaceutical Nanotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran [Field not mapped to EPrints] AD - Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran [Field not mapped to EPrints] AD - Kimia Research Institute, P.O. Box 51665-171, Tabriz, Iran [Field not mapped to EPrints] AD - Medway School of Pharmacy, Universities of Kent and Greenwich, Central Ave., Kent ME4 4TB, United Kingdom [Field not mapped to EPrints] AD - Department of Chemistry, University of North Texas, Denton, TX 76203-5070, United States [Field not mapped to EPrints] JA - Chem. Pharm. Bull. [Field not mapped to EPrints]
Uncontrolled keywords: Binary solvent, Paracetamol, Solubility prediction, Ternary solvent, alcohol, paracetamol, propylene glycol, water, accuracy, article, drug mixture, drug solubility, mathematical model, prediction, solvent effect, Acetaminophen, Algorithms, Analgesics, Non-Narcotic, Chemistry, Pharmaceutical, Ethanol, Forecasting, Models, Chemical, Propylene Glycols, Solubility, Solvents, Temperature, Water
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 29 Dec 2013 18:35 UTC
Last Modified: 29 May 2019 08:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/29425 (The current URI for this page, for reference purposes)
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