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Solubility prediction of paracetamol in water-glycerol mixtures at 25 and 30 °c using the jouyban-acree model

Jouyban, Abolghasem, Fakhree, Mohammad A. A., Mirzaei, Shahla, Ghafourian, Taravat, Soltanpour, S., Nokhodchi, Ali (2009) Solubility prediction of paracetamol in water-glycerol mixtures at 25 and 30 °c using the jouyban-acree model. Asian Journal of Chemistry, 21 (9). pp. 7249-7253. ISSN 09707077 (ISSN). (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Abstract

The solubility of paracetamol in water-glycerol mixtures at 25 and 30 °C was determined using flask shake method. The generated data extended the solubility database for further computational investigations and was also used to assess the prediction capability of a trained version of the Jouyban-Acree model for solubility prediction in water-glycerol mixtures at various temperatures. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation between the predicted and experimental solubilities. The overall mean percentage deviation of the Jouyban-Acree model for the back-calculated solubility data from the literature was 37.9 ± 21.9%. The corresponding value for the predicted solubilities of paracetamol in binary mixtures using experimental values of paracetamol solubilities in water and glycerol was 15.6 ± 11.1%.

Item Type: Article
Additional information: Unmapped bibliographic data: PY - 2009/// [EPrints field already has value set] AD - Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran [Field not mapped to EPrints] AD - Kimia Research Institute, Tabriz, Iran [Field not mapped to EPrints] AD - Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [Field not mapped to EPrints] AD - Medway School of Pharmacy, Universities of Kent and Greenwich, Kent, United Kingdom [Field not mapped to EPrints] AD - Faculty of Pharmacy, Zanjan University (Medical Sciences), Zanjan, Iran [Field not mapped to EPrints] JA - Asian J. Chem. [Field not mapped to EPrints]
Uncontrolled keywords: Binary solvents, Jouyban-acree model, Paracetamol, Solubility prediction
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 29 Dec 2013 17:32 UTC
Last Modified: 29 May 2019 08:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/29421 (The current URI for this page, for reference purposes)
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