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Solubility of 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4- oxide,7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one in (propane-1,2-diol + water) at a temperature of 303.2 K

Jouyban, Abolghasem, Shokri, Javad, Barzegar-Jalali, Mohammad, Hassanzadeh, Davoud, Acree, William Eugene, Ghafourian, Taravat, Nokhodchi, Ali (2010) Solubility of 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4- oxide,7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one in (propane-1,2-diol + water) at a temperature of 303.2 K. Journal of Chemical and Engineering Data, 55 (1). pp. 539-542. ISSN 00219568 (ISSN). (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Abstract

Experimental solubilities of 7-chloro-2-methylamino-5-phenyl-3H-1,4- benzodiazepine-4-oxide (chlordiazepoxide), 7-chloro-1,3-dihydro-1-methyl-5- phenyl-2H-1,4-benzodiazepin-2-one (diazepam), and 7-chloro- 5-(2-chlorophenyl)- 3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one (lorazepam) in (propane-1,2-diol + water) at T = 303.2 K were reported. The solubility of drugs increased with the addition of propane-1,2-diol and reached the maximum values in pure propane-1,2-diol. The Jouyban-Acree model was used to fit the experimental data, and the solubilities were reproduced using a previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the back-calculated and predicted values with the corresponding experimental data were 4.2% and 10.7%. The solubilities of the three drugs were also predicted using a trained version of the log-linear model of Yalkowsky, and the OMRD was 21.1%. © 2010 American Chemical Society.

Item Type: Article
Additional information: Unmapped bibliographic data: PY - 2010/// [EPrints field already has value set] AD - Faculty of Pharmacy and Drug Applied Research Center, Tabriz University (Medical Sciences), Tabriz 51664, Iran [Field not mapped to EPrints] AD - Biotechnology Research Center, Tabriz University (Medical Sciences), Tabriz 51664, Iran [Field not mapped to EPrints] AD - Research Center for Pharmaceutical Nanotechnology, Tabriz University (Medical Sciences), Tabriz 51664, Iran [Field not mapped to EPrints] AD - Department of Chemistry, University of North Texas, Denton, TX 76203-5070, United States [Field not mapped to EPrints] AD - Medway School of Pharmacy, Universities of Kent and Greenwich, Kent ME4 4TB, United Kingdom [Field not mapped to EPrints] JA - J Chem Eng Data [Field not mapped to EPrints]
Uncontrolled keywords: Experimental data, Jouyban-Acree model, Loglinear model, Lorazepam, Maximum values, Relative deviations, Solubility data, Propane, Regression analysis, Ternary systems, Solubility
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 29 Dec 2013 17:29 UTC
Last Modified: 29 May 2019 08:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/29420 (The current URI for this page, for reference purposes)
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