Skip to main content

Solubility of benzodiazepines in polyethylene glycol 200 + water mixtures at 303.2 K

Jouyban, Abolghasem, Shokri, Javad, Barzegar-Jalali, Mohammad, Hassanzadeh, Davoud, Acree, William Eugene, Ghafourian, Taravat, Nokhodchi, Ali (2010) Solubility of benzodiazepines in polyethylene glycol 200 + water mixtures at 303.2 K. Journal of Chemical and Engineering Data, 55 (1). pp. 519-522. ISSN 00219568 (ISSN). (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://www.scopus.com/inward/record.url?eid=2-s2.0...

Abstract

Experimental solubilities of chlordiazepoxide, diazepam, and lorazepam in polyethylene glycol 200 (PEG 200) + water mixtures at 303.2 K were reported. The solubility of each drug increased exponentially with the addition of PEG 200 and reached the maximum value in neat PEG 200. The Jouyban-Acree model was used to mathematically describe the experimental data, and the solubilities were predicted using a previously trained version of the Jouyban-Acree model for PEG + water mixtures and the solubility data in monosolvents. The overall mean relative deviations of the models were 3.7% and 18.3%, respectively, for the fitted model and the trained version. © 2010 American Chemical Society.

Item Type: Article
Additional information: Unmapped bibliographic data: PY - 2010/// [EPrints field already has value set] AD - Faculty of Pharmacy and Drug Applied Research Center, Tabriz University (Medical Sciences), Tabriz 51664, Iran [Field not mapped to EPrints] AD - Biotechnology Research Center, Tabriz University (Medical Sciences), Tabriz 51664, Iran [Field not mapped to EPrints] AD - Research Center for Pharmaceutical Nanotechnology, Tabriz University (Medical Sciences), Tabriz 51664, Iran [Field not mapped to EPrints] AD - Department of Chemistry, University of North Texas, Denton, TX 76203-5070, United States [Field not mapped to EPrints] AD - Medway School of Pharmacy, Universities of Kent and Greenwich, Kent ME4 4TB, United Kingdom [Field not mapped to EPrints] JA - J Chem Eng Data [Field not mapped to EPrints]
Uncontrolled keywords: Benzodiazepines, Experimental data, Jouyban-Acree model, Lorazepam, Maximum values, PEG 200, Polyethylene glycol 200, Relative deviations, Solubility data, Water mixture, Mixtures, Polyethylene oxides, Solubility, Ternary systems, Thermoplastics, Polyethylene glycols
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 29 Dec 2013 17:27 UTC
Last Modified: 29 May 2019 08:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/29419 (The current URI for this page, for reference purposes)
  • Depositors only (login required):