Skip to main content

Solubility prediction of clonazepam in aqueous mixtures of ethanol, polyethylene glycol 200 and propylene glycol at 30°C

Jouyban, Abolghasem, Shokri, Javad, Barzegar-Jalali, Mohammad, Hassanzadeh, Davoud, Acree, William Eugene, Ghafourian, Taravat, Nokhodchi, Ali (2010) Solubility prediction of clonazepam in aqueous mixtures of ethanol, polyethylene glycol 200 and propylene glycol at 30°C. Journal of Drug Delivery Science and Technology, 20 (2). pp. 149-151. ISSN 17732247 (ISSN). (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://www.scopus.com/inward/record.url?eid=2-s2.0...

Abstract

Solubility of clonazepam in aqueous binary mixtures of ethanol, polyethylene glycol 200 and propylene glycol was determined at 30°C using the shake flask method. The maximum solubility of clonazepam was observed at volume fraction of 0.90 ofethanol, whereas for aqueous mixtures of polyethylene glycol 200 and propylene glycol, the maximum values were observed in the neat cosolvents. The generated data was fitted to the Jouyban-Acree model and its constants were computed, then the back-calculated solubilities were compared with the corresponding experimental values by calculating the mean percentage deviation (MPD) in which the overall MPD for three cosolvent systems was 7.0 %. The solubility data in cosolvent + water mixtures was predicted using previously trained versions of the Jouyban-Acree model and the prediction MPDs were 13.4, 542 and 24.9 %, respectively for ethanol, polyethylene glycol 200 and propylene glycol mixtures and the overall MPD was 30.8 %.

Item Type: Article
Additional information: Unmapped bibliographic data: PY - 2010/// [EPrints field already has value set] AD - Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran [Field not mapped to EPrints] AD - Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran [Field not mapped to EPrints] AD - Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz 51664, Iran [Field not mapped to EPrints] AD - Department of Chemistry, University of North Texas, Denton, TX 76203-5070, United States [Field not mapped to EPrints] AD - Medway School of Pharmacy, Universities of Kent and Greenwich, Kent ME4 4TB, United Kingdom [Field not mapped to EPrints] JA - J. Drug Deliv. Sci. Technol. [Field not mapped to EPrints]
Uncontrolled keywords: Clonazepam, Cosolvent, Jouyban-Acree model, Solubility, Solubilization, alcohol, clonazepam, macrogol 200, propylene glycol, solvent, article, drug solubility, mathematical model, prediction, temperature
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 29 Dec 2013 17:25 UTC
Last Modified: 29 May 2019 08:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/29418 (The current URI for this page, for reference purposes)
  • Depositors only (login required):