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Copy number variation, chromosome rearrangement, and their association with recombination during avian evolution

Völker, Martin, Backström, Niclas, Skinner, Benjamin M., Langley, Elizabeth J, Bunzey, Sydney K., Ellegren, Hans, Griffin, Darren K. (2010) Copy number variation, chromosome rearrangement, and their association with recombination during avian evolution. Genome Research, 20 (4). pp. 503-511. (doi:10.1101/gr.103663.109) (KAR id:29310)

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http://dx.doi.org/10.1101/gr.103663.109

Abstract

Chromosomal rearrangements and copy number variants (CNVs) play key roles in genome evolution and genetic disease; however, the molecular mechanisms underlying these types of structural genomic variation are not fully understood. The availability of complete genome sequences for two bird species, the chicken and the zebra finch, provides, for the first time, an ideal opportunity to analyze the relationship between structural genomic variation (chromosomal and CNV) and recombination on a genome-wide level. The aims of this study were therefore threefold: (1) to combine bioinformatics, physical mapping to produce comprehensive comparative maps of the genomes of chicken and zebra finch. In so doing, this allowed the identification of evolutionary chromosomal rearrangements distinguishing them. The previously reported interchromosomal conservation of synteny was confirmed, but a larger than expected number of intrachromosomal rearrangements were reported; (2) to hybridize zebra finch genomic DNA to a chicken tiling path microarray and identify CNVs in the zebra finch genome relative to chicken; 32 interspecific CNVs were identified; and (3) to test the hypothesis that there is an association between CNV, chromosomal rearrangements, and recombination by correlating data from (1) and (2) with recombination rate data from a high-resolution genetic linkage map of the zebra finch. We found a highly significant association of both chromosomal rearrangements and CNVs with elevated recombination rates. The results thus provide support for the notion of recombination-based processes playing a major role in avian genome evolution. © 2010 by Cold Spring Harbor Laboratory Press.

Item Type: Article
DOI/Identification number: 10.1101/gr.103663.109
Additional information: Unmapped bibliographic data: PY - 2010/// [EPrints field already has value set] AD - School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom [Field not mapped to EPrints] AD - Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden [Field not mapped to EPrints] AD - Mammalian Molecular Genetics Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom [Field not mapped to EPrints] AD - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SA, United Kingdom [Field not mapped to EPrints]
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Darren Griffin
Date Deposited: 06 Jun 2013 09:48 UTC
Last Modified: 16 Nov 2021 10:07 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/29310 (The current URI for this page, for reference purposes)
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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