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Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38*

Nachtigall, Jonny, Kulik, Andreas, Helaly, Soleiman, Bull, Alan T., Goodfellow, Michael, Asenjo, Juan A., Maier, Armin, Wiese, Jutta, Imhoff, Johannes F., Sussmuth, Roderich D., and others. (2011) Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38*. Journal of Antibiotics, 64 (12). pp. 775-780. ISSN 0021-8820. (doi:10.1038/ja.2011.96) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29214)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
http://dx.doi.org/10.1038/ja.2011.96

Abstract

Three new 22-membered macrolactone antibiotics, atacamycins A–C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells.

Item Type: Article
DOI/Identification number: 10.1038/ja.2011.96
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Susan Davies
Date Deposited: 27 Mar 2012 15:28 UTC
Last Modified: 16 Nov 2021 10:07 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/29214 (The current URI for this page, for reference purposes)
Bull, Alan T.: https://orcid.org/0000-0001-6223-7722
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