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Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview

von der Haar, Tobias (2012) Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview. Computational and Structural Biotechnology Journal, 1 (1). e201204002. ISSN 2001-0370. (doi:10.5936/csbj.201204002)

Abstract

Translation or protein synthesis consists of a complex system of chemical reactions, which ultimately result in decoding of the mRNA and the production of a protein. The complexity of this reaction system makes it difficult to quantitatively connect its input parameters (such as translation factor or ribosome concentrations, codon composition of the mRNA, or energy availability) to output parameters (such as protein synthesis rates or ribosome densities on mRNAs). Mathematical and computational models of translation have now been used for nearly five decades to investigate translation, and to shed light on the relationship between the different reactions in the system. This review gives an overview over the principal approaches used in the modelling efforts, and summarises some of the major findings that were made.

Item Type: Article
DOI/Identification number: 10.5936/csbj.201204002
Subjects: Q Science > Q Science (General)
Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Tobias von der Haar
Date Deposited: 24 Feb 2012 13:36 UTC
Last Modified: 01 Aug 2019 10:34 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/28964 (The current URI for this page, for reference purposes)
von der Haar, Tobias: https://orcid.org/0000-0002-6031-9254
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