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Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935.

Nachtigall, Jonny, Schneider, Kathrin, Bruntner, Christina, Bull, Alan T., Goodfellow, Michael, Zinecker, Heidi, Imhoff, Johannes F., Nicholson, Graeme, Irran, Elisabeth, Sussmuth, Roderich D., and others. (2011) Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935. Journal of Antibiotics, 64 (6). pp. 453-457. ISSN 0021-8820. (doi:10.1038/ja.2011.26) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1038/ja.2011.26

Abstract

Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-ray analysis. The compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3? and a weak antiproliferative activity against mouse fibroblast cells.

Item Type: Article
DOI/Identification number: 10.1038/ja.2011.26
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: Sue Davies
Date Deposited: 30 Jun 2011 10:24 UTC
Last Modified: 29 May 2019 08:36 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/27997 (The current URI for this page, for reference purposes)
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