Nachtigall, Jonny, Schneider, Kathrin, Bruntner, Christina, Bull, Alan T., Goodfellow, Michael, Zinecker, Heidi, Imhoff, Johannes F., Nicholson, Graeme, Irran, Elisabeth, Sussmuth, Roderich D., and others. (2011) Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935. Journal of Antibiotics, 64 (6). pp. 453-457. ISSN 0021-8820. (doi:10.1038/ja.2011.26) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:27997)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://dx.doi.org/10.1038/ja.2011.26 |
Abstract
Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-ray analysis. The compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3? and a weak antiproliferative activity against mouse fibroblast cells.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1038/ja.2011.26 |
| Subjects: | Q Science |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Susan Davies |
| Date Deposited: | 30 Jun 2011 10:24 UTC |
| Last Modified: | 16 Nov 2021 10:06 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/27997 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Bull, Alan T..
| Creator's ORCID: |
 https://orcid.org/0000-0001-6223-7722
|
|---|---|
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