Validation of the growth hormone (GH)-dependent marker method of detecting GH abuse in sport through the use of independent data sets

Erotokritou-Mulligan, Ioulietta and Bassett, Eryl E. and Kniess, Astrid and Sonksen, Peter H. and Holt, Richard I. G. (2007) Validation of the growth hormone (GH)-dependent marker method of detecting GH abuse in sport through the use of independent data sets. Growth Hormone & IGF Research, 17 (5). 416-423 . ISSN 1096-6374 . (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Context: The detection of exogenously administered growth hormone (GH) poses a formidable challenge but a detection method based on the measurement of two GH-dependent markers, IGF-I and type 3 pro-collagen (P-III-P) has been proposed. The measurement of multiple markers in conjunction with discriminant functions can improve the sensitivity and specificity of detection compared with single marker analysis. Objective: To provide further validation of the GH-dependent marker approach. Design: Analysis of discriminant function scores for GH detection on independent datasets. Setting: Two independent (GH-2000 and Kreischa) double blind, placebo controlled, hGH administration studies. Subjects: Healthy active male volunteers. Intervention: GH-2000 proposed a discriminant function involving IGF-I and P-III- P while the Kreischa function involved IGF-I, P-III-P and IGFBP-3. After adjustment for assay differences the formulae were applied to the other dataset. Outcome measures: Ability to detect GH use in independent datasets using a predefined specificity of approximately 1 in 10000. Results: The GH-2000 formula was able to detect 90% of those receiving GH in the Kreischa study at one or more time points during the study period. This sensitivity was similar to that obtained on the original GH-2000 dataset. The Kreischa formula correctly identified 41% of individuals receiving GH in the GH-2000 study. Conclusions: The study provides further validation that the test proposed by GH-2000 based on IGF-I and P-III-P concentrations can be used to detect subjects receiving exogenous GH.

Item Type: Article
Uncontrolled keywords: growth hormone; sport; abuse; discriminant function; markers
Subjects: Q Science > QA Mathematics (inc Computing science)
Q Science > QH Natural history > QH301 Biology
Divisions: Faculties > Science Technology and Medical Studies > School of Mathematics Statistics and Actuarial Science > Statistics
Depositing User: Louise Dorman
Date Deposited: 24 Apr 2008 08:22
Last Modified: 08 May 2014 11:27
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