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Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids

Innocenti, Alessio, Leewattanapasuk, Worraanong, Manole, Gheorghe, Scozzafava, Andrea, Mühlschlegel, Fritz A., Supuran, Claudiu T. (2010) Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids. Bioorganic & Medicinal Chemistry Letters, 20 (5). pp. 1701-1704. ISSN 0960-894X. (doi:10.1016/j.bmcl.2010.01.054) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:27484)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/j.bmcl.2010.01.054

Abstract

The protein encoded by the NCE103 gene of Candida glabrata, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as CgCA, was investigated for its activation with amines and amino acids. CgCA was weakly activated by amino acids such as l-/d-His, l-Phe, l-DOPA, and l-Trp and by histamine or dopamine (K(A)s of 21.2-37microM) but more effectively activated by d-Phe, d-DOPA, d-Trp as well as serotonin, pyridyl-alkylamines, aminoethyl-piperazine/morpholine (K(A)s of 10.1-16.7microM). The best activators were l-/d-Tyr, with activation constants of 7.1-9.5microM. This study may bring a better understanding of the catalytic/activation mechanisms of beta-CAs from pathogenic fungi

Item Type: Article
DOI/Identification number: 10.1016/j.bmcl.2010.01.054
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Susan Davies
Date Deposited: 29 Jun 2011 16:35 UTC
Last Modified: 16 Nov 2021 10:05 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/27484 (The current URI for this page, for reference purposes)

University of Kent Author Information

Mühlschlegel, Fritz A..

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