High-intensity exercise and carbohydrate-reduced energy-restricted diet in obese individuals.

Sartor, Francesco and de Morree, Helma M. and Matschke, Verena and Marcora, Samuele Maria and Milousis, Athanasios and Thom, Jeanette M. and Kubis, Hans-Peter (2010) High-intensity exercise and carbohydrate-reduced energy-restricted diet in obese individuals. European Journal of Applied Physiology, 110 (5). pp. 893-903. ISSN 1439-6319. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Continuous high glycemic load and inactivity challenge glucose homeostasis and fat oxidation. Hyperglycemia and high intramuscular glucose levels mediate insulin resistance, a precursor state of type 2 diabetes. The aim was to investigate whether a carbohydrate (CHO)-reduced diet combined with high-intensity interval training (HIIT) enhances the beneficial effects of the diet alone on insulin sensitivity and fat oxidation in obese individuals. Nineteen obese subjects underwent 14 days of CHO-reduced and energy-restricted diet. Ten of them combined the diet with HIIT (4 min bouts at 90% VO(2peak) up to 10 times, 3 times a week). Oral glucose insulin sensitivity (OGIS) increased significantly in both groups; [diet-exercise (DE) group: pre 377 ± 70, post 396 ± 68 mL min(-1) m(-2); diet (D) group: pre 365 ± 91, post 404 ± 87 mL min(-1) m(-2); P < 0.001]. Fasting respiratory exchange ratio (RER) decreased significantly in both groups (DE group: pre 0.91 ± 0.06, post 0.88 ± 0.06; D group: pre 0.92 ± 0.07, post 0.86 ± 0.07; P = 0.002). VO(2peak) increased significantly in the DE group (pre 27 ± 5, post 32 ± 6 mL kg(-1) min(-1); P < 0.001), but not in the D group (pre 26 ± 9, post 26 ± 8 mL kg(-1) min(-1)). Lean mass and resistin were preserved only in the DE group (P < 0.05). Fourteen days of CHO-reduced diet improved OGIS and fat oxidation (RER) in obese subjects. The energy-balanced HIIT did not further enhance these parameters, but increased aerobic capacity (VO(2peak)) and preserved lean mass and resistin.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Q Science > QP Physiology (Living systems)
R Medicine > RC Internal medicine
Divisions: Faculties > Science Technology and Medical Studies > School of Sport and Exercise Sciences
Depositing User: Samuele Marcora
Date Deposited: 21 Jan 2011 10:29
Last Modified: 17 Feb 2015 14:33
Resource URI: https://kar.kent.ac.uk/id/eprint/26251 (The current URI for this page, for reference purposes)
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