Skip to main content

Simulating biology: towards understanding what the simulation shows

Andrews, Paul S. and Polack, Fiona and Sampson, Adam T. and Scott, Lisa and Coles, Mark (2008) Simulating biology: towards understanding what the simulation shows. In: Stepney, Susan and Polack, Fiona and Welch, Peter, eds. Cosmos 2008 : Complex Systems Modelling and Simulation. Luniver Press, pp. 93-123. ISBN 978-1-905986-17-0. (KAR id:24106)


When building simulations of complex systems the task of validation is often overlooked. Validation helps provide confidence in the simulation by exploring the link between the models that we build and the real complex system. We investigate software engineering validation techniques from outside the area of complex systems to assess their applicability for the types of simulation we build. We then provide an example of how such techniques can be applied to a complex systems simulation of cells migrating from blood vessels into lymph nodes through the walls of the blood vessels. We suggest that explicitly stating the modelling and simulation assumptions we make is key to the process of validation. Concluding, we highlight a possible process for validating complex systems that explicitly incorporates environmental aspects.

Item Type: Book section
Uncontrolled keywords: complex-systems simulation validation modelling
Subjects: Q Science > QA Mathematics (inc Computing science) > QA 76 Software, computer programming,
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Depositing User: Mark Wheadon
Date Deposited: 29 Mar 2010 12:15 UTC
Last Modified: 16 Nov 2021 10:02 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Sampson, Adam T..

Creator's ORCID:
CReDIT Contributor Roles:
  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.