Top-down hierarchical ensembles of classifiers for predicting G-Protein-Coupled-Receptor functions

Costa, Eduardo P. and Lorena, Ana C. and Carvalho, Andre C. P. L. F. and Freitas, Alex A. (2008) Top-down hierarchical ensembles of classifiers for predicting G-Protein-Coupled-Receptor functions. In: Advances in Bioinformatics and Computational Biology (Proc. 2008 Brazilian Symposium in Bioinformatics (BSB-2008)), Lecture Notes in Bioinformatics 5167, Aug 28-30, 2008, Santo Andre, Brazil. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Despite the recent advances in Molecular Biology, the function of a large amount of proteins is still unknown. An approach that can be used in the prediction of a protein function consists of searching against secondary databases, also known as signature databases. Different strategies can be applied to use protein signatures in the prediction of function of proteins. A sophisticated approach consists of inducing a classification model for this prediction. This paper applies five hierarchical classification methods based on the standard Top-Down approach and one hierarchical classification method based on a new approach named Top-Down Ensembles - based on the hierarchical combination of classifiers - to three different protein functional classification datasets that employ protein signatures. The algorithm based on the Top-Down Ensembles approach presented slightly better results than the other algorithms, indicating that combinations of classifiers can improve the performance of hierarchical classification models.

Item Type: Conference or workshop item (Paper)
Uncontrolled keywords: classification, bioinformatics
Subjects: Q Science > QA Mathematics (inc Computing science) > QA 76 Software, computer programming,
Divisions: Faculties > Science Technology and Medical Studies > School of Computing > Applied and Interdisciplinary Informatics Group
Depositing User: Mark Wheadon
Date Deposited: 29 Mar 2010 12:12
Last Modified: 26 Jun 2014 12:02
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