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Improvements in breast cancer survival over time, related to adjuvant treatment and node status

Imkampe, Anne Kathrin, Bates, Tom (2009) Improvements in breast cancer survival over time, related to adjuvant treatment and node status. European Journal of Surgical Oncology, 35 (2). pp. 151-155. ISSN 0748-7983. (doi:10.1016/j.ejso.2008.02.010) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:23623)

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Background: There has been an increase in the use and effectiveness of adjuvant treatment for operable breast cancer and the aim of this

study was to examine whether this has resulted in improved survival for all prognostic groups.

Methods: A retrospective study of 1517 patients with invasive breast cancer treated between 1980 and 2002 was carried out. The use of

adjuvant treatment was compared between two time periods in patients based on nodal status, and survival was calculated by Kaplane

Meier life table analysis. Independent predictors for recurrence-free survival (RFS) were determined by Cox regression analysis.

Results: The use of adjuvant therapy increased for all prognostic groups. On multivariate analysis the use of radiotherapy and endocrine

therapy was positively associated with RFS which was significant in the second time period. Outcome in node positive patients improved:

five-year RFS from 59% to 76%, p < 0.01 and breast cancer specific survival (BCSS) from 70% to 83%, p < 0.01. However, there was no

survival improvement in the larger group of node negative patients; BCSS 93% versus 95%, p ¼ 0.99. Within the node negative group,

patients with tumours ? 2 cm had an improved RFS from 80% to 88%, p ¼ 0.02.

Conclusion: The increased use of adjuvant therapy was associated with an improved outcome in node positive patients. For node negative

patients with good prognostic features the evidence of benefit was marginal.

Item Type: Article
DOI/Identification number: 10.1016/j.ejso.2008.02.010
Subjects: R Medicine > RD Surgery
R Medicine
Divisions: Divisions > Directorate of Education > School of Education
Depositing User: Bates Tom
Date Deposited: 29 Jun 2011 13:19 UTC
Last Modified: 16 Nov 2021 10:02 UTC
Resource URI: (The current URI for this page, for reference purposes)

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