Hewes, J.C., Imkampe, Anne Kathrin, Haji, A., Bates, Tom (2008) Importance of Routine Cavity Sampling in Breast Conservation Surgery. British Journal of Surgery, 96 (1). pp. 47-53. ISSN 0007-1323. E-ISSN 1365-2168. (doi:10.1002/bjs.6435) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:23622)
PDF
Publisher pdf
Language: English Restricted to Repository staff only |
|
|
|
Official URL: http://dx.doi.org/10.1002/bjs.6435 |
Abstract
Background: The role of cavity biopsy (CB) at the time of wide local excision (WLE) for primary breast
cancer has not been evaluated fully. This study compared four groups of patients to determine the
significance of margins and CB histology on tumour characteristics and outcome.
Methods: This was a retrospective study of patients undergoing WLE and CB in one institution
over 21 years. Demographic data, tumour characteristics and survival information were obtained. Four
subgroups of patients were compared according to their margin and cavity status (positive or negative).
Results: A total of 957 patients had WLE. The median 10-year survival was 85·6 per cent and breast
cancer-specific survival was 92·4 per cent. Tumour size, grade, node and oestrogen receptor status
were independent predictors of survival. There was poor concordance between positivity of resection
margins and CB (32·0 per cent); a negative margin carried a 10·8 per cent risk of demonstrable residual
disease. A positive CB, but not a positive margin, was associated with reduced overall survival and breast
cancer-specific survival.
Conclusion: Cavity status wasmore significant with regard to survival than margin status.CB is important
in identifying residual and multifocal disease, as margin and cavity positivity are often not concordant.
Item Type: | Article |
---|---|
DOI/Identification number: | 10.1002/bjs.6435 |
Subjects: |
R Medicine > RD Surgery R Medicine |
Divisions: | Divisions > Directorate of Education > School of Education |
Depositing User: | Bates Tom |
Date Deposited: | 29 Jun 2011 13:19 UTC |
Last Modified: | 16 Nov 2021 10:02 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/23622 (The current URI for this page, for reference purposes) |
- Export to:
- RefWorks
- EPrints3 XML
- BibTeX
- CSV
- Depositors only (login required):