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Importance of Routine Cavity Sampling in Breast Conservation Surgery

Hewes, J.C., Imkampe, Anne Kathrin, Haji, A., Bates, Tom (2008) Importance of Routine Cavity Sampling in Breast Conservation Surgery. British Journal of Surgery, 96 (1). pp. 47-53. ISSN 0007-1323. E-ISSN 1365-2168. (doi:10.1002/bjs.6435) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:23622)

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Abstract

Background: The role of cavity biopsy (CB) at the time of wide local excision (WLE) for primary breast

cancer has not been evaluated fully. This study compared four groups of patients to determine the

significance of margins and CB histology on tumour characteristics and outcome.

Methods: This was a retrospective study of patients undergoing WLE and CB in one institution

over 21 years. Demographic data, tumour characteristics and survival information were obtained. Four

subgroups of patients were compared according to their margin and cavity status (positive or negative).

Results: A total of 957 patients had WLE. The median 10-year survival was 85·6 per cent and breast

cancer-specific survival was 92·4 per cent. Tumour size, grade, node and oestrogen receptor status

were independent predictors of survival. There was poor concordance between positivity of resection

margins and CB (32·0 per cent); a negative margin carried a 10·8 per cent risk of demonstrable residual

disease. A positive CB, but not a positive margin, was associated with reduced overall survival and breast

cancer-specific survival.

Conclusion: Cavity status wasmore significant with regard to survival than margin status.CB is important

in identifying residual and multifocal disease, as margin and cavity positivity are often not concordant.

Item Type: Article
DOI/Identification number: 10.1002/bjs.6435
Subjects: R Medicine > RD Surgery
R Medicine
Divisions: Divisions > Directorate of Education > School of Education
Depositing User: Bates Tom
Date Deposited: 29 Jun 2011 13:19 UTC
Last Modified: 16 Nov 2021 10:02 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/23622 (The current URI for this page, for reference purposes)
Bates, Tom: https://orcid.org/0000-0001-5554-1945
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