Williams, T.C., Jarvis, Simon M. (1991) Multiple Sodium-Dependent Nucleoside Transport-Systems in Bovine Renal Brush-Border Membrane-Vesicles. Biochemical Journal, 274 (1). pp. 27-33. ISSN 0264-6021. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:22800)
The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. |
Abstract
Na+-dependent nucleoside transport was examined in bovine renal brush-border membrane vesicles. Two separate Na+/nucleoside cotransporters were shown to be present: (1) a system specific for purine nucleosides and uridine, designated as the N1 carrier, and (2) an Na+-dependent nucleoside transporter that accepts pyrimidine nucleosides, adenosine and analogues of adenosine, designated as the N2 system. Both systems exhibit a high affinity for nucleosides (apparent K(m) values approximately 10-mu-M), are insensitive to inhibition by facilitated-diffusion nucleoside transport inhibitors, are rheogenic and exhibit a high specificity for Na+. Na+ increases the affinity of the influx of guanosine and thymidine, nucleosides that serve as model permeants for the N1 and N2 nucleoside transporters respectively. The Na+/nucleoside coupling stoichiometry is consistent with 1:1 for both carriers.
Item Type: | Article |
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Subjects: | Q Science > QP Physiology (Living systems) > QP517 Biochemistry |
Divisions: | Divisions > Division of Natural Sciences > Biosciences |
Depositing User: | P. Ogbuji |
Date Deposited: | 29 Sep 2009 07:03 UTC |
Last Modified: | 16 Nov 2021 10:01 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/22800 (The current URI for this page, for reference purposes) |
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