Neuregulins in the nucleus

McClelland, C.M. and Gullick, William J. (2009) Neuregulins in the nucleus. In: Giordano, A. and Normanno, Nicola, eds. Breast Cancer in the Post-genomic Era. Current Clinical Oncology . Humanna Press, USA, pp. 79-86. ISBN 9781603279444. (Access to this publication is restricted)

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Official URL http://dx.doi.org/10.1007/978-1-60327-945-1_5

Abstract

The neuregulins are a subset of the ligands for the epidermal growth factor receptor family of receptors. They can bind to these receptors and evoke a range of cellular responses. Some of the neuregulins have however been found in the cell nucleus associated with nucleoli and intrachromatin granules. This brief review summarises the data for nuclear expression obtained from observations on normal and malignant tissues and the various laboratory experiments conducted to explore the system. Finally, we discuss the possible functions that could result from intra-nuclear expression of these molecules.

Item Type:	Book section
Uncontrolled keywords:	Neuregulin - Heregulin - NRG - Growth factor - Growth factor receptor - Breast cancer
Subjects:	Q Science R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User:	Bill Gullick
Date Deposited:	25 Sep 2009 18:04
Last Modified:	15 Jul 2014 14:14
Resource URI:	https://kar.kent.ac.uk/id/eprint/22653 (The current URI for this page, for reference purposes)