Neuregulins in the nucleus

McClelland, C.M. and Gullick, William J. (2009) Neuregulins in the nucleus. In: Giordano, A. and Normanno, Nicola, eds. Breast Cancer in the Post-genomic Era. Current Clinical Oncology . Humanna Press, USA, pp. 79-86. ISBN 978-1-60327-944-4. (doi:10.1007/978-1-60327-945-1_5) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:22653)

PDF (Neuregulins in the Nucleus) Language: English Restricted to Repository staff only

Official URL: http://dx.doi.org/10.1007/978-1-60327-945-1_5

Abstract

The neuregulins are a subset of the ligands for the epidermal growth factor receptor family

of receptors. They can bind to these receptors and evoke a range of cellular responses. Some of

the neuregulins have however been found in the cell nucleus associated with nucleoli and intrachromatin

granules. This brief review summarises the data for nuclear expression obtained from

observations on normal and malignant tissues and the various laboratory experiments conducted to

explore the system. Finally, we discuss the possible functions that could result from intra-nuclear

expression of these molecules.

Item Type:	Book section
DOI/Identification number:	10.1007/978-1-60327-945-1_5
Uncontrolled keywords:	Neuregulin - Heregulin - NRG - Growth factor - Growth factor receptor - Breast cancer
Subjects:	Q Science R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	William Gullick
Date Deposited:	25 Sep 2009 18:04 UTC
Last Modified:	16 Nov 2021 10:01 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/22653 (The current URI for this page, for reference purposes)

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