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One for all? A viral protein supplants the mRNA cap-binding complex

von der Haar, Tobias (2009) One for all? A viral protein supplants the mRNA cap-binding complex. Embo Journal, 28 (1). pp. 6-7. ISSN 0261-4189. (doi:10.1038/emboj.2008.251)

Abstract

Modulation of the host cell’s translational machinery is a crucial part of viral infection strategies.Well-characterised mechanisms that aid viruses in manipulating translational activity include, for example, internal ribosomal entry sites, which allow viral RNA translation in the absence of some or many of the canonical host translation factors. New research shows that the nucleocapsid protein from a species of Hantavirus can replace several host cell translation factors in in vitro translation reactions, suggesting that hantaviruses may have evolved a novel strategy for modulating host cell translation in the form of a multifunctional translation factor.

Item Type: Article
DOI/Identification number: 10.1038/emboj.2008.251
Projects: [121] 075438
Subjects: Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Divisions: Faculties > Sciences > School of Biosciences > Protein Science Group
Depositing User: Tobias von der Haar
Date Deposited: 27 Oct 2009 16:01 UTC
Last Modified: 01 Aug 2019 10:33 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/22644 (The current URI for this page, for reference purposes)
von der Haar, Tobias: https://orcid.org/0000-0002-6031-9254
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