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A role for actin in aging and apoptosis

Gourlay, Campbell W., Ayscough, Kathryn R. (2005) A role for actin in aging and apoptosis. Biochemical Society Transactions, 33 (6). pp. 1260-1264. ISSN 0300-5127. (doi:10.1042/BST0331260)

Abstract

The actin cytoskeleton is central to many cell processes including membrane trafficking and generation of cell polarity. We have identified a role for actin in cell death and in promoting longevity of the budding yeast, Saccharomyces cerevisiae. Aging in yeast appears to occur via an apoptotic-like pathway with changes including DNA fragmentation, loss of mitochondrial membrane permeability, increase in levels of ROS (reactive oxygen species) and exposure of phosphatidylserine in the outer leaflet of the plasma membrane. This pathway can be induced by alterations in actin dynamics, such that reduced dynamics correlates with increased levels of ROS and decreased viability. Conversely, increased actin dynamics correlates with low ROS levels and increased survival. Our current studies have focused on identifying pathways which couple changes in actin dynamics to cell death.

Item Type: Article
DOI/Identification number: 10.1042/BST0331260
Additional information: onference Information: BioScience 2005 Conference Glasgow, SCOTLAND, JUL 17-21, 2005
Uncontrolled keywords: actin; aging; apoptosis; mitochondrion; programmed cell death; senescence
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Campbell Gourlay
Date Deposited: 29 Sep 2009 15:56 UTC
Last Modified: 19 Jun 2019 14:01 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/22641 (The current URI for this page, for reference purposes)
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