Antifungal drug development - the identification of new targets

Tuite, Mick F. (1992) Antifungal drug development - the identification of new targets. Trends in Biotechnology, 10 (7). pp. 235-239. ISSN 0167-7799. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Abstract

With the increasing prevalence of life-threatening systemic fungal infections in the human population, there is a need to develop new, more-effective antifungal agents. This, in turn, will depend upon the identification and exploitation of new antifungal targets - aspects of fungal cytology, metabolism and gene expression which are important for fungal pathogenesis, but which have no mammalian host counterpart. Such new targets have been identified through a combination of classical genetic, cytological and biochemical studies and are reviewed here, as is the potential for applying recombinant DNA techniques as a means of confirming the role of the identified gene products in pathogenesis.

Item Type:	Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Divisions:	Faculties > Sciences > School of Biosciences
Depositing User:	O.O. Odanye
Date Deposited:	27 Jul 2009 22:33 UTC
Last Modified:	10 Jun 2014 13:05 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/22260 (The current URI for this page, for reference purposes)